Excess Weight Hikes Cardiac Risk All on Its Own
Published: Nov 11, 2013 | Updated: Nov 12, 2013, By Elizabeth DeVita Raeburn, Contributing Writer, MedPage Today, Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania and Dorothy Caputo, MA, BSN, RN, Nurse Planner
Being overweight or obese were risk factors for myocardial infarction (MI) and ischemic heart disease (IHD), even in the absence of metabolic syndrome, researchers found.
Among participants with and without metabolic syndrome, there were "increasing and cumulative incidences" of both MI and IHD along the continuum of weight from normal to obese (log-rank trend P=0.006 and P<0.001 respectively), according to Borge G. Nordestgaard, MD, DMSc, and his co-author, Mette Thomsen, MD, both of Copenhagen University Hospital.
In participants without metabolic syndrome, the hazard ratios for MI compared with normal weight participants were 1.26 (95% CI, 1.00-1.61) in overweight individuals and 1.88 (95% CI, 1.34-2.63) in those who were obese, they wrote online in JAMA Internal Medicine.
The hazard ratios for MI among those with metabolic syndrome were 1.39 (95% CI, 0.96-2.02) in those of normal weight, 1.70 (95% CI, 1.35-2.15) in the overweight, and 2.33 (95% CI, 1.81-3.00) in obese participants.
"For IHD, results were similar but attenuated," the authors wrote, possibly because the diagnostic criteria for IHD include subjective symptoms of angina pectoris, which could have resulted in misclassification. Overall, the findings suggest that "metabolic syndrome is no more valuable than BMI in identifying individual risk," the authors wrote.